Peer-Reviewed Studies ARCHIVED

Read the Most Recent Peer-Reviewed Studies for TAP Oral Appliances

TAP devices are the most researched oral appliances on the market with more than 45 independent peer-reviewed published studies and counting.

Since 1997, all clinical trials involving the TAP have been conducted by independent investigators who do not have a financial interest in the device. Each study was funded by an outside source and not by Airway Management. We believe in the ability of our products to help patients sleep better, and we’re proud to know that the experts do, too.

In 2015, AASM (American Academy of Sleep Medicine) and AADSM (American Academy of Dental Sleep Medicine) guidelines cite TAP as leading among oral appliances using both oral appliance and CPAP criteria.

Browse our TAP bibliography, or download the printable version.


IN: Sleep Breath. 2022 Jan 11. doi: 10.1007/s11325-021-02548-0. Epub ahead of print. PMID: 35013898.


Julia A.M. Uniken Venema, Boudewijn R.A.M. Rosenmöller, Nico de Vries, Jan de Lange, Ghizlane Aarab, Frank Lobbezoo, Aarnoud Hoekema. Mandibular advancement device design: A systematic review on outcomes in obstructive sleep apnea treatment.
IN: Sleep Medicine Reviews, Volume 60, 2021, 101557, ISSN 1087-0792.


Schramm, P.; Das, N.; Schneiderman, E.; German, Z.; Hui, J.; Wilson, D.; Spencer, J.; Moura, P.; Chapman, S.B. Snoring Remediation with Oral Appliance Therapy Potentially Reverses Cognitive Impairment: An Intervention Controlled Pilot Study.

IN: Geriatrics 2021, 6, 107.


Wojciech Trzepizur , Peter A. Cistulli, Martin Glos, Bruno Vielle, Kate Sutherland, Peter J. Wijkstra, Aarnoud Hoekema and Frédéric Gagnadoux. Health outcomes of continuous positive airway pressure versus mandibular advancement device for the treatment of severe obstructive sleep apnea: an individual participant data meta-analysis.

In: SLEEPJ, 2021, 1-7


Schneiderman, E., Schramm, P., Hui, J., Wilson, P. D., Moura, P., German, Z., McCann, A., & Newton, M. (2021). Randomized Trial of 2 Self-Titrated Oral Appliances for Airway Management. 

IN: Journal of Dental Research100(2), 155–162.



Venema, Julia A. M. Uniken, Et al.  – Long-Term Obstructive Sleep Apnea Therapy: A 10-year Follow Up of Mandibular Advancement Device and Continuous Positive Airway Pressure. 

In: Journal of Clinical Sleep Medicine 15 March 2020 



Kanti V. Obstructive Sleep Apnea in a patient with orofacial pain secondary to cervical fixation.

In: JADA 148 (3), 185-189



Hoekema, A., Wijkstra P., et al. Continuous Positive Airway Pressure and Oral Appliance Hybrid Therapy in Obstructive Sleep Apnea: Patient Comfort Compliance and Preference: A Pilot Study 

In: Journal of Dental Sleep Medicine, 2016 3(1): 5-10


Hogg James J. Remote Controlled Mandibular Positional Device to Determine Oral Appliance Efficacy and Therapeutic Protrusive Position

In: Journal of Dental Sleep Medicine, 2016 3(1): 29-30



Kent D., Rogers R., Loose R. Drug-Induced Sedation Endoscopy in the Evaluation of OSA Patients with Incomplete Oral Appliance Therapy Response.

In: Sleep Rev 2015 (5) 18-21


Sanders AE, Denbar MA, White J, Prehn RS, Rogers RR, Pardue T, et alDental clinicians’ observations of combination therapy in PAP-intolerant patients

In: Otolaryngology – Head and Neck Surgery. Vol 153 (2): 302-307


Prehn R., Colquitt T. Fabrication technique for a custom face mask for the treatment of Obstructive Sleep Apnea

In: The Journal of Prosthetic Dentistry.



Verrett R., Smith Y. Evaluation of a Novel Device for Measuring Patient Compliance with Oral Appliances in the Treatment of Obstructive Sleep Apnea. 

In: Journal of Prosthodontics 23 (2014) 31-38



Boota A. White JR, Pardue T, Essick G. Sustained tolerance of CPAP using MAS supported Nasal Pillows. Abstract. 26th Annual APSS Meeting, Boston, MA


Bender S. Oral Appliance Therapy for Sleep-Related Breathing Disorders. 

In: Elsevier, Operative Techniques in Otolaryngology, (2012) 23, 72-78



White JR, Boota A, Essick G. Efficacy and Tolerance of Combination Therapy using MAS Supported Nasal Pillows.

At: American Academy of Dental Sleep Medicine Annual Meeting. (Awarded: Poster, Abstract of the Year), Minneapolis, MN 2011


Holley AB, Lettieri CJ, Shah AA. Efficacy of an Adjustable Oral Appliance and Comparison to Continuous Positive Airway Pressure for the Treatment of Obstructive Sleep Apnea Syndrome

In: Chest DOI 10.1378/chest.10-2851, June 2, 2011


Lettieri CJ, Paolino N, Eliasson AH, Shah AA, Holley, AB. Comparison of Adjustable and Fixed Oral Appliances for the Treatment of Obstructive Sleep Apnea Syndrome.

In: Journal of Clinical Sleep Medicine, JCSM, October 2011



Bishop B, Verrett R, Girvan T, Ingmundson P. Crossover Study Comparing Two Oral Appliance Designs for Treatment of Obstructive Sleep Apnea.

At: American Academy of Dental Sleep Medicine Annual Meeting. San Antonio, TX; 2010


Chung JW, Enciso R, Levendowski DJ, Westbrook PR, Clark GT. Treatment outcomes of mandibular advancement devices in positional and nonpositional OSA patients

In: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 May; 109(5):724-31


McLornan P, Verrett R, Girvan T, Ingmundson P. Evaluation of Obstructive Sleep Apnea Patients’ Oral Appliance Titration Protocols

At: The American Academy of Dental Sleep Medicine Annual Meeting. San Antonio, TX; 2010


Prehn R. The New TAP-PAP Custom Face Mask for CPAP Compliance and Satisfaction.

At: American Academy of Dental Sleep Medicine Annual Meeting. San Antonio, TX; 2010



Ghazal A, Sorichter S, Jonas I, Rose EC. A randomized prospective long-term study of two oral appliances for sleep apnea treatment.

In: J Sleep Res. 2009 Sep; 18(3):321-8


Krishnan, V., N. A. Collop, et al. An evaluation of a titration strategy for prescription of oral appliances for obstructive sleep apnea.

In: Chest 2009 133(5): 1135-1141



Chung JW, Enciso R, Levendowski DJ, Westbrook PR, Clark GT. Investigation of positional and non-positional OSA: risk factors associated with apnea-hypopnea severity.

In: Journal of Sleep Research, 2008


Ghazal A, Jonas IE, Rose EC. Dental side effects of mandibular advancement appliances – a 2 year follow-up.

In: J Orofac Orthop. 2008 Nov; 69(6):437-47


Hoekema, A., B. Stegenga, et al. Obstructive sleep apnea therapy.

In: Journal of Dental Research, 2008 87(9): 882-887


Hoekema, A., A. A. Voors, et al. Effects of oral appliances and CPAP on the left ventricle and natriuretic peptides.

In: Int J Cardiol 2008 128(2): 232-239



Hoekema A, Doff MHJ, Bont LGMd, Hoeven JHvd, Wijkstra PJ, Pasma HR, et al. Predictors of Obstructive Sleep Apnea-Hypopnea Treatment Outcome

In: J Dent Res 2007; 86(12):1181-1186


Hoekema A, Stegenga B, Bakker M, Brouwer WH, Bont LGMd, Wijkstra PJ, et al. Simulated driving in obstructive sleep apnea – hypopnoea; effects of oral appliances and continuous positive airway pressure

In: Sleep and Breathing 2007; 11(3):129-138


Hoekema A, Stel A-L, Stegenga B, Hoeven JHvd, Wijkstra PJ, Driel MFv, et al. Sexual Function and Obstructive Sleep Apnea – Hypopnea: A Randomized Clinical Trial Evaluating the Effects of Oral-Appliance and Continuous Positive Airway Pressure Therapy.

In: The Journal of Sexual Medicine 2007; 4(4ii):1153-1162


Hoekema A, Vries Fd, Heydenrijk K, Stegenga B. Implant-retained oral appliances: a novel treatment for edentulous patients with obstructive sleep apnea – hypopnea syndrome

In: Clinical Oral Implants Research 2007; 18(3):383-387


Levendowski DJ, Morgan TD, Patrickus JE, Westbrook PR, Berka C, Zavora T, et al. In-home evaluation of efficacy and titration of a mandibular advancement device for obstructive sleep apnea. 

In: Sleep Breath 2007; 11(3):139-47


Stouder, Jones, Brietzke, Mair. Does an oral appliance reduce palatal flutter and tongue base snoring? 

In: Otolaryngology – Head and Neck Surgery 2007; 136(5):827-831



*Barnes M, McEvoy RD, Banks S et al. Efficacy of Positive Airway Pressure and Oral Appliance in Mild to Moderate Obstructive Sleep Apnea.

In: Am J Respir Crit Care Med 2004; 170:656-664


Conaway JR, Scherr SC. Multidisciplinary Management of the Airway in a Trauma-Induced Brain Injury Patient

In: Sleep Breath 2004; 8(3):165-170


Rose EC, Germann M, Sorichter S, Jonas IE. Case Control Study in the Treatment of Obstructive Sleep-Disordered Breathing with a Mandibular Protrusive Appliance.

In: Journal of Orofacial Orthopedics 2004; 65(6):489-500



Denbar MA. A Case Study Involving the Combination Treatment of an Oral Appliance and Auto-Titrating CPAP Unit.

In: Sleep Breath 2002; 6(3):125-128


Gershman. Prospective Study of the TAP in the Management of Obstructive Sleep Apnea and Snoring.

In: Sleep 2002; 25(Supplement):A466


Skinner MA, Robertson CJ, Kingshott RN, Jones DR, Taylor DR. The efficacy of a mandibular advancement splint in relation to cephalometric variables

In: Sleep Breath 2002;6(3):115-24



Pancer J, Al-Faifi S, Al-Faifi M, Hoffstein V. Evaluation of Variable Mandibular Advancement Appliance for Treatment of Snoring and Sleep Apnea.

In: Chest 1999; 116(6):1511-1518



Denbar M. Case report: Utilization of the Thornton Adjustable Positioner in maintaining the airway for a child with obstructive apnea, micrognathia, and cerebral palsy.

In: Tex Dent J. 1998; 115(10):21-22


Roberts DH, Becker PM, Jamieson AO. Determining Efficacy of a Split Night OA & CPCP Titration Protocol Using PSG.

In: Sleep 1998; 21(Supplement):97



Thornton WK, Roberts DH. – Nonsurgical management of the obstructive sleep apnea patient.

In: Journal of Oral and Maxillofacial Surgery 1996; 54(9):1103-1108

This appliance is a TAP-based design.