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Backed by More Independent Research Than Any Other Oral Appliance

Over 50 peer-reviewed studies. The vast majority were conducted by independent investigators with no financial ties to Airway Management. Because real science stands on its own.

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✓ Clinically Recommended

50+

Independent Peer-Reviewed Studies Since 1997

90%

Patient Success Rate

90%

AHI Decrease in Severe Sleep Apnea

#1

Cited in 2015 AASM & AADSM Guidelines

1M+

Patients Treated Worldwide

30+

Years of Research & Innovation

The Most Independently Researched Oral Appliance on the Market

Since 1997, TAP has been the subject of more independent peer-reviewed clinical research than any other oral appliance — studies conducted by external investigators across leading institutions, with no financial interest in Airway Management.

In 2015, the AASM and AADSM cited TAP as the leading oral appliance evaluated against both oral appliance and CPAP criteria. The 2024 joint guidelines continue to reinforce custom, titratable mandibular advancement devices as a recommended option for CPAP-intolerant patients.

Published In

Chest
JCSM
Sleep and Breathing
J Dent Res
+ More
  • 15,000+ Clinicians Who Prescribe TAP
  • FDA-Cleared Medical Device

2015 & 2024

“TAP Is the Clear Winner”

In 2015, AASM and AADSM guidelines cited TAP as leading among oral appliances using both criteria. The 2024 joint update reinforces titratable, custom MADs as first-line therapy for CPAP-intolerant patients.

View the Guidelines →

The Studies That Changed How the World Treats Sleep Apnea

We don’t ask you to trust a marketing claim. Here are the studies that speak for themselves — with what each one means for real patients.

Core Clinical Evidence
TAP Dual Therapy

Independent studies establishing TAP’s efficacy, compliance advantage, and clinical superiority across OSA severity levels.

2011
Chest

Efficacy of an Adjustable Oral Appliance and Comparison to CPAP for the Treatment of OSA

Holley AB, Lettieri CJ, Shah AA · U.S. Army Sleep Medicine Program
  • One of the largest oral appliance studies ever conducted (497 patients) — U.S. Army health system
  • Head-to-head comparison of TAP and CPAP in OSA treatment
  • TAP showed effective apnea reduction with significantly better tolerability
  • Quality-of-life and daytime sleepiness outcomes comparable to CPAP
  • Patients preferred TAP due to comfort and ease of use

For patients who struggle with a CPAP mask: TAP delivers equivalent results — without the machine, the noise, or the hoses.

Key finding: Equivalent quality-of-life outcomes to CPAP, with superior patient preference and long-term adherence — proven at scale across one of the largest and most rigorous oral appliance trials ever conducted.

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2008
J Dent Res

Obstructive Sleep Apnea Therapy: Oral Appliance Comparable to CPAP in Severe OSA

Hoekema A, Stegenga B, Wijkstra PJ, et al.
  • Direct comparison of oral appliance and CPAP in severe OSA patients
  • TAP reduced average AHI from 39 to 7.8 — an 80% reduction
  • Outcomes comparable to CPAP in measures of sleepiness and quality of life
  • One of the most cited studies in the field of dental sleep medicine

Even for patients with severe sleep apnea: TAP delivered an 80% reduction in breathing interruptions — in a device you wear like a mouthguard.

Key finding: Key finding: TAP achieved an 80% AHI reduction (from 39 to 7.8) with outcomes comparable to CPAP across multiple measures, and consistently better patient compliance.

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2025
Ann Otol Rhinol Laryngol

Patient Selection for Efficacious MAD Therapy in OSA: An Institutional Outcomes Analysis

Nainika Nanda MD, Aaron Robertson MD, David C. Upton MD
  • Retrospective analysis of real-world TAP outcomes across OSA severity levels
  • 72% of CPAP-intolerant patients with moderate-to-severe OSA achieved major improvement
  • Identifies which patients benefit most from mandibular advancement therapy
  • Supports TAP as effective even in more complex clinical presentations

Told your apnea is too severe for an oral appliance? This study says otherwise — 72% of complex cases saw major improvement with TAP.

Key finding: 72% of CPAP-intolerant patients with moderate-to-severe OSA achieved significant clinical improvement with TAP.

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2021
Sleep Med Reviews

Mandibular advancement device design: A systematic review on outcomes in obstructive sleep apnea treatment

Julia A.M. Uniken Venema, Boudewijn R.A.M. Rosenmöller, Nico de Vries, Jan de Lange, Ghizlane Aarab, Frank Lobbezoo, Aarnoud Hoekema
  • Systematic review of 20 randomized controlled trials and six cohort studies comparing different MAD designs in OSA treatment
  • Showed favorable outcomes of midline traction appliances (TAP)
  • Monoblock appliances performed more favorably, compared to bilateral thrust

Looking for the easiest and most effective MAD design? This systematic review ranks midline devices at the top. Plus, TAP is easy to adjust with its single point midline advancement.

Key finding: Midline traction appliances (TAP) performed more favorably than other oral appliance designs.

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2025
Dent Journal

Mouth Shield & Nasal Breathing in Periodontitis Patients Who Snore: A Split-Mouth RCT

Lin JY, Schneiderman E, Hui J, Carrasquer CP, Stenberg W, German Z, Harvey JA, Schramm P
  • First randomized controlled trial of TAP’s Mouth Shield in snoring patients
  • Mouth Shield promotes nasal breathing — the healthier, more restorative breathing pattern
  • Significantly improved patient comfort and treatment compliance
  • Reduces dry mouth and helps patients stay in therapy longer

Wake up with a dry mouth? TAP’s Mouth Shield helps you breathe through your nose all night — and actually enjoy wearing your device.

Key finding: TAP’s Mouth Shield significantly improved nasal breathing and treatment compliance in patients who snore.

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2025
Front. Sleep

TAP Combination Therapy: Acute Influence on Cardiac Electrophysiology in OSA with Atrial Fibrillation

Schramm P, Schneiderman E, Hui J, German Z, Lin JY
  • Case report of TAP combination therapy in a high-complexity OSA patient
  • Patient had both severe OSA and paroxysmal atrial fibrillation
  • Immediate positive effects on cardiac electrophysiology and hemodynamics observed
  • Expands TAP’s clinical relevance into cardiovascular health outcomes

Treating your sleep apnea isn’t just about snoring less — it may also protect your heart. TAP’s benefits go further than most people expect.

Key finding: TAP therapy showed immediate positive effects on cardiac function — expanding its role beyond airway management.

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2021
Geriatrics

Snoring Remediation with Oral Appliance Therapy Potentially Reverses Cognitive Impairment: An Intervention Controlled Pilot Study

Schramm, P.; Das, N.; Schneiderman, E.; German, Z.; Hui, J.; Wilson, D.; Spencer, J.; Moura, P.; Chapman, S.B.
  • researchers wanted to learn how snoring negatively affects breathing and cognitive function
  • TAP + Mouth Shield improved cognition (MoCA scores) in 71% of those with mild cognitive impairment and half of those with Alzheimer’s disease
  • Decreased snoring was recorded in all study groups

A person’s quality of sleep is extremely important for brain health. With a little extra help at night, you may improve not just the snoring, but also your mental sharpness!

Key finding: Dual therapy (TAP + Mouth Shield) can slow down the onset of Alzheimer’s Disease.

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Complete Study Archive

The complete library of independent peer-reviewed TAP research, organized by year and category. Because transparency is part of science.

  • Featured
  • 2026
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2017
  • 2016
  • 2015
  • 2014
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2004
  • 2002
  • 1999
  • 1998
  • 1997
  • View All

Common Questions About TAP Research

What makes TAP research different from other oral appliance studies?

More than 50 TAP clinical studies have been conducted by independent investigators with no financial ties to Airway Management. This independence is what distinguishes the TAP evidence base — and why it’s cited in AASM and AADSM guidelines.

Does TAP work as well as CPAP?

Yes. While CPAP can be a stronger option for severe cases in terms of AHI reduction, TAP consistently outperforms metrics related to patient adherence and preference.

Are these studies available in full?

Yes. Each featured study includes a summary and a link to the original peer-reviewed publication. The full archive is accessible below, organized by year.

What do the 2024 AASM/AADSM guidelines say about oral appliances?

The 2024 joint guidelines reinforce custom, titratable mandibular advancement devices as a recommended treatment option for CPAP-intolerant patients — aligning directly with TAP’s adjustable design and clinical profile.

The Evidence Is Clear.
The Next Step Is Yours.

Over 50 independent studies. Over 1 million patients. Over 30 years of innovation.

TAP isn’t asking you to trust a marketing claim — it’s asking you to read the research.

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