It is well established that oral appliance therapy (OAT) is effective in treating obstructive sleep apnea (OSA) of all severities if the patient is compliant. Despite the availability of recommendations for promoting compliance there are no true guidelines or templates. A suggested protocol is presented here that is intended to maximize compliance. The goal of this Oral Appliance Compliance Protocol (OCP) is not to minimize discomfort or perceived pain but rather motivate the patient to wear the appliance as much as possible during sleep. The elements of the OCP are detailed here and the response to it in 509 patients in a single dental practice is summarized.